Curation Information

Catabolite repression in Lactobacillus casei ATCC 393 is mediated by CcpA.;Monedero V, Gosalbes MJ, Pérez-Martínez G;Journal of bacteriology 1997 Nov; 179(21):6657-64 [9352913]
CcpA [Q03AX7, view regulon]
Reported TF sp.
Lactobacillus casei ATCC 393
Reported site sp.
Lactobacillus casei ATCC 393
Created by
Dinara Sagitova
Curation notes

Experimental Process

Visual inspection of the lacTEGF promoter identified a putative CcpA binding site with one mismatch to the CcpA consensus sequence. GUS reporter assays in the wild-type and ccpA mutant strains showed that repression by CcpA was abolished in the ccpA mutant strain.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
ATAAAACGTTTACA lact, lacE, lacG, lacF,
... ... lact lacE lacG lacF epsG
Experimental technique details GUS reporter gene assay (ECO:0005641) - Experimental technique details Visual sequence inspection (nan) - repressor not specified