Researchers used a consensus search of the CRE box (CcpA binding site) in the pneumoniae genome to compile a list of genes with CRE boxes in the promoter. They then cross-referenced that list with the results (trimmed to only significant results) of a DNA-array that compared wt to a CcpA deletion.
Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.
| Site sequence | Regulated genes | Gene diagram | Experimental techniques | TF function | TF type |
|---|---|---|---|---|---|
| ATATAATCGCTATCAA | strH, |
|
repressor | dimer | |
| AAGAATGCGTTTTTAT | celA, |
|
repressor | dimer | |
| TTGTAAACGGTTTCTA | SPD_0286, |
|
repressor | dimer | |
| GAGAAAGGGTTTACAT | fba, |
|
repressor | dimer | |
| TATTAAACGCTTCCAA | atpE, |
|
repressor | dimer |