Curation Information

Publication
Arginine-dependent gene regulation via the ArgR repressor is species specific in chlamydia.;Schaumburg CS, Tan M;Journal of bacteriology 2006 Feb; 188(3):919-27 [16428395]
TF
ArgR [Q9Z8Z1, view regulon]
Reported TF sp.
Chlamydophila caviae GPIC
Reported site sp.
Chlamydophila caviae GPIC
Created by
Dinara Sagitova
Curation notes
-

Experimental Process

Two putative ArgR binding sites were predicted by visual inspection of the glnPQ promoter region. EMSA demonstrated that C. pneumoniae ArgR was able to bind to the predicted C. caviae glnPQ operators in a concentration-dependent manner with a binding affinity similar to that of the C. pneumoniae operators.

Transcription Factor Binding Sites


ACTGCATGATTATGCTTT
AGTAAATAAATATGCATG
ACTGCATGATTATGCTTT
AGTAAATAAATATGCATG

Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
ACTGCATGATTATGCTTT
... ... argR gcp_2 CCA00541 glnP glnQ
Experimental technique details EMSA (ECO:0001807) - Experimental technique details Visual sequence inspection (nan) - not specified not specified
AGTAAATAAATATGCATG
... ... glnP glnQ
Experimental technique details EMSA (ECO:0001807) - Experimental technique details Visual sequence inspection (nan) - not specified not specified