Curation Information

Heat and DNA damage induction of the LexA-like regulator HdiR from Lactococcus lactis is mediated by RecA and ClpP.;Savijoki K, Ingmer H, Frees D, Vogensen FK, Palva A, Varmanen P;Molecular microbiology 2003 Oct; 50(2):609-21 [14617183]
HdiR [A2RKI6, view regulon]
Reported TF sp.
Lactococcus lactis subsp. cremoris MG1363
Reported site sp.
Lactococcus lactis subsp. cremoris MG1363
Created by
Erill Lab
Curation notes

Experimental Process

Northern blot shows differential expression when the system is induced with mit-C or heat-shock. The binding site was predicted based on visual inspection due to its highly palindromic nature. EMSA with purified HdiR and fragments of different length show that the IR1 region is bound by HdiR.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... hdiR llmg_1205
Experimental technique details EMSA (ECO:0001807) - Experimental technique details Northern blot (ECO:0005653) - Experimental technique details Visual sequence inspection (nan) - repressor dimer