Curation Information

The PerR regulon in peroxide resistance and virulence of Streptococcus pyogenes.;Brenot A, King KY, Caparon MG;Molecular microbiology 2005 Jan; 55(1):221-34 [15612930]
PerR [Q9A1M6, view regulon]
Reported TF sp.
Streptococcus pyogenes M1 GAS
Reported site sp.
Streptococcus pyogenes M1 GAS
Created by
Dinara Sagitova
Curation notes
The expression of the csp gene was shown to be regulated by PerR. However, during the submission process collecTF search did not include this region within the range of identified genes.

Experimental Process

DNase I footprinting confirmed binding. qPCR showed that PerR is a transcriptional activator of the csp gene cluster.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... SPy_t57 ahpC nox1 hutI
Experimental technique details DNAse footprinting (ECO:0005631) - Experimental technique details qPCR [quantitative real-time] (ECO:0005660) - activator not specified