Curation Information

Iron-responsive repression of urease expression in Helicobacter hepaticus is mediated by the transcriptional regulator Fur.;Belzer C, van Schendel BA, Kuipers EJ, Kusters JG, van Vliet AH;Infection and immunity 2007 Feb; 75(2):745-52 [17101656]
Fur [Q7VHS0, view regulon]
Reported TF sp.
Helicobacter hepaticus ATCC 51449
Reported site sp.
Helicobacter hepaticus ATCC 51449
Created by
Dinara Sagitova
Curation notes

Experimental Process

Iron-responsive repression of urease activity was shown by deleting fur gene. EMSA showed that Fur binds the site on the ureA promoter. DNase I footprinting was used to identify Fur binding site within the promoter region.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... ureA HH0406 HH0405 HH0404 HH0403 HH0402 ureB ureI ureE ureF ureG ureH nikE nikD nikB nikA HH0418 proB fmt birA parA parB atpF atpF' atpH atpA atpG atpD atpC HH0431 HH0432 HH0433 tolB HH0435 HH0436 slyD
Experimental technique details DNAse footprinting (ECO:0005631) - Experimental technique details EMSA (ECO:0001807) - Experimental technique details Primer Extension assay (ECO:0005657) - repressor not specified