Curation Information

A Fur-like protein PerR regulates two oxidative stress response related operons dpr and metQIN in Streptococcus suis.;Zhang T, Ding Y, Li T, Wan Y, Li W, Chen H, Zhou R;BMC microbiology 2012 May 30; 12():85 [22646062]
PerR [A4VT39, view regulon]
Reported TF sp.
Streptococcus suis 05ZYH33
Reported site sp.
Streptococcus suis 05ZYH33
Created by
Dinara Sagitova
Curation notes
The expression of the metQIN promoter was shown to be regulated by PerR. However, during the submission process collecTF search did not include this operon within the range of the identified genes.

Experimental Process

The consensus sequence of the PerR-box in S. pyogenes and B. subtilis was used to screen S. suis genome for putative PerR boxes. RT-PCR was performed to validate PerR-dependent transcription regulation of the identified genes. EMSAs showed that PerR could bind to its target promoters.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... SSU05_1773 SSU05_1772 SSU05_1774 SSU05_1775
Experimental technique details EMSA (ECO:0001807) - Experimental technique details PSSM site search (ECO:0005659) - Experimental technique details qRT-PCR [RNA] (ECO:0001808) - repressor not specified