Curation Information

Mutation analysis of the Pseudomonas aeruginosa mvfR and pqsABCDE gene promoters demonstrates complex quorum-sensing circuitry.;Xiao G, He J, Rahme LG;Microbiology (Reading, England) 2006 Jun; 152(Pt 6):1679-86 [16735731]
LasR [P25084, view regulon]
Reported TF sp.
Pseudomonas aeruginosa UCBPP-PA14
Reported site sp.
Pseudomonas aeruginosa UCBPP-PA14
Created by
Erill Lab
Curation notes

Experimental Process

A previously reported LasR was known to be necessary to activate mvfR transcription using beta-gal assays coupled to site-directed mutagenesis.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... mvfR pqsB pqsC pqsD pqsE phnA phnB PA14_51320 nadA pqsA
Experimental technique details Beta-gal reporter assay - Experimental technique details Site directed mutagenesis (ECO:0005667) - activator not specified