Curation Information

CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.;Liu T, Ramesh A, Ma Z, Ward SK, Zhang L, George GN, Talaat AM, Sacchettini JC, Giedroc DP;Nature chemical biology 2007 Jan; 3(1):60-8 [17143269]
CsoR [P9WP49, view regulon]
Reported TF sp.
Mycobacterium tuberculosis H37Rv
Reported site sp.
Mycobacterium tuberculosis H37Rv
Created by
Erill Lab
Curation notes
External databases
Protein Data Bank (2HH7) .

Experimental Process

Visual sequence inspection of a promoter region shown to be involved in copper resistance allowed identification of a potential palindromic binding site. EMSAs showed that the purified Rv0967 gene product (CsoR) binds specifically to this region, and that binding is copper dependent. GFP revealed that CsoR drives represses its own operon. The crystal structure of CsoR shows that it binds as a homodimer

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... Rv0968 csoR Rv0970 ctpV Rv0963c Rv0964c Rv0965c Rv0966c
Experimental technique details EMSA (ECO:0001807) - Experimental technique details GFP Promoter Fusion (ECO:0005636) - Experimental technique details Visual sequence inspection (nan) - Experimental technique details X-ray crystallography (ECO:0005670) - repressor dimer