Curation Information

Cell cycle-dependent transcriptional and proteolytic regulation of FtsZ in Caulobacter.;Kelly AJ, Sackett MJ, Din N, Quardokus E, Brun YV;Genes & development 1998 Mar 15; 12(6):880-93 [9512521]
CtrA [P0CAW8, view regulon]
Reported TF sp.
Caulobacter crescentus NA1000
Reported site sp.
Caulobacter crescentus NA1000
Created by
Dinara Sagitova
Curation notes

Experimental Process

Visual inspection of the ftsZ promoter identified a sequence with the perfect match to the CtrA consensus binding site. DNase I footprinting confirmed that CtrA binds to the predicted binding site. ftsZ-xylX fusion assays using ftsZ promoter in which CtrA binding site was deleted showed that ftsZ expression was 1.7-fold higher than in the wild-type strain.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... ftsZ CCNA_02622
Experimental technique details DNAse footprinting (ECO:0005631) - Experimental technique details Visual sequence inspection (nan) - Experimental technique details xylE reporter assay - repressor not specified