Curation Information

Cell cycle control by an essential bacterial two-component signal transduction protein.;Quon KC, Marczynski GT, Shapiro L;Cell 1996 Jan 12; 84(1):83-93 [8548829]
CtrA [P0CAW8, view regulon]
Reported TF sp.
Caulobacter crescentus CB15
Reported site sp.
Caulobacter crescentus CB15
Created by
Dinara Sagitova
Curation notes

Experimental Process

Beta-gal reporter assay identified that CtrA can act as both a positive and a negative regulator of the fliQ, fliL, and hemE expression. The authors suggested that the function of CtrA may switch between positive and negative regulation as it expression changes during the cell cycle. DNase I footprinting experiment showed that CtrA protected a region in the fliQ promoter which contains a sequence resembling the CtrA binding motif.

Transcription Factor Binding Sites


Gene Regulation

Regulated genes for each binding site are displayed below. Gene regulation diagrams show binding sites, positively-regulated genes, negatively-regulated genes, both positively and negatively regulated genes, genes with unspecified type of regulation. For each indvidual site, experimental techniques used to determine the site are also given.

Site sequence Regulated genes Gene diagram Experimental techniques TF function TF type
... ... fliQ flhB fliR CC_1078
Experimental technique details Beta-gal reporter assay - Experimental technique details DNAse footprinting (ECO:0005631) - Experimental technique details Visual sequence inspection (nan) - dual not specified